Ernest O. Lawrence pioneered the creation of ever greater particle accelerating devices beginning in 1932 . The first cyclotron could actually be held in your hand, today these are giant machines, burried along tens of miles of underground tunnel.
 The Production of High Speed Light Ions Without the Use of High Voltages, Ernest O. Lawrence and M. Stanley Livingston, 1932, American Physical Society.
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The First Cyclotron, American Institute of Physics.